Highly Pathogenic Influenza Viruses Inhibit Inflammatory Response in Monocytes via Activation of Rar-Related Orphan Receptor RORa
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چکیده
منابع مشابه
Risk Assessment of the Introduction and Spread of Highly Pathogenic Avian Influenza Viruses (H5-Subtypes) Via Migratory Birds in Iran
Background and Objectives: HPAI has economic and public health importance. Aquatic and shore migratory birds are the main reservoirs and the cause of the spread of viruses across countries. The aim of study was risk assessment of the spread of the avian influenza H5 viruses. Methods: In this qualitative study, structured interviews and focus group discussions were used to assess the risk of...
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Experience with influenza has shown that predictions of virus phenotype or fitness from nucleotide sequence are imperfect and that predicting the timing and course of evolution is extremely difficult. Such uncertainty means that the risk of experiments with mammalian-transmissible, possibly highly virulent influenza viruses remains high even if some aspects of their laboratory biology are reass...
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A mutation in the nuclear orphan receptor RORa results in a severe impairment of cerebellar development by unknown mechanisms. We have shown previously that RORa contains a strong constitutive activation domain in its C terminus. We therefore searched for mammalian RORa coactivators using the minimal activation domain as bait in a two-hybrid screen. Several known and putative coactivators were ...
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Understanding of ecologic factors favoring emergence and maintenance of highly pathogenic avian influenza (HPAI) viruses is limited. Although low pathogenic avian influenza viruses persist and evolve in wild populations, HPAI viruses evolve in domestic birds and cause economically serious epizootics that only occasionally infect wild populations. We propose that evolutionary ecology considerati...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2013
ISSN: 1662-811X,1662-8128
DOI: 10.1159/000346706